Training host-pathogen protein–protein interaction predictors

Training large margin host-pathogen protein-protein interaction predictors

ABDUL HANNAN BASIT, WAJID ARSHAD ABBASI, AMINA ASIF, AND FAYYAZ UL AMIR AFSAR MINHAS † Biomedical Informatics Research Laboratory, Department of Computer and Information Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Nilore, Islamabad, Pakistan Department of Electrical Engineering, Pakistan Institute of Engineer-ing and Applied Sciences (PIEAS), Nilore, Islamabad, 440...

Chromatin Remodelling During Host-Bacterial Pathogen Interaction

Host–Pathogen Interaction in Invasive Salmonellosis

Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever, caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is a bacteremic illness but whose clinical features differ from other Gram-negative bacteremias. Non-typhoidal Salmonella (NTS) serovars cause self-limiting diarrhea with occasional secondary bacteremia. Primary NTS bacteremia can occur in t...

Protein Disulfide Isomerase and Host-Pathogen Interaction

Reactive oxygen species (ROS) production by immunological cells is known to cause damage to pathogens. Increasing evidence accumulated in the last decade has shown, however, that ROS (and redox signals) functionally regulate different cellular pathways in the host-pathogen interaction. These especially affect (i) pathogen entry through protein redox switches and redox modification (i.e., intra-...

Dermatophytes: host-pathogen interaction and antifungal resistance.

Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host de...